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Critical role of plasmacytoid dendritic cells in induction of oral tolerance
Authors:Tomofumi Uto  Hideaki Takagi  Tomohiro Fukaya  Junta Nasu  Takehito Fukui  Noriaki Miyanaga  Keiichi Arimura  Takeshi Nakamura  Narantsog Choijookhuu  Yoshitaka Hishikawa  Katsuaki Sato
Affiliation:1. Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan;2. Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan;3. Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan;4. Division of Histochemistry and Cell Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan;5. Japan Agency for Medical Research and Development (AMED), Tokyo, Japan
Abstract:
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  • Keywords:Mucosal immunity  oral tolerance  dendritic cells  regulatory T cells  allergy  ALDH  Aldehyde dehydrogenase  APC  Antigen-presenting cell  BALF  Bronchoalveolar lavage fluid  cDC  Conventional dendritic cells  CFA  Complete Freund adjuvant  DC  Dendritic cell  DT  Diphtheria toxin  DTH  Delayed-type hypersensitivity  EGFP  Enhanced green fluorescent protein  Foxp3  Forkhead box p3  GALT  Gut-associated lymphoid tissues  IDO  Indoleamine 2,3-dioxygenase  iTreg  Inducible regulatory T  LP  Lamina propria  MLN  Mesenteric lymph node  OVA  Ovalbumin  OVAp  pDC  Plasmacytoid dendritic cell  PGN  Peptidoglycan  RA  Retinoic acid  siLP  Lamina propria of the small intestine  TCR  T-cell receptor  Teff  Effector T  TLR  Toll-like receptor  Treg  Regulatory T
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