| 雷公藤多甙、藻酸双酯钠对大鼠受损动脉内膜增生的影响 |
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| 引用本文： | 王人彭,朱国英,汪丽蕙. 雷公藤多甙、藻酸双酯钠对大鼠受损动脉内膜增生的影响[J]. 中国介入心脏病学杂志, 1996, 0(4) |
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| 作者姓名： | 王人彭 朱国英 汪丽蕙 |
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| 作者单位： | 北京医科大学第一医院心内科(王人彭)，江苏省徐州市心血管病研究所(朱国英，汪丽蕙) |
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| 摘 要： | 31只大鼠行胸主动脉内皮剥脱术,随机分为对照组10只、雷公藤多甙组10只(9.4 mg/kg/d)和藻酸双酯钠组11只(30mg/kg/d).后两组于术前6天开始喂药.于术后14天观察各组大鼠胸主动脉新生内膜面积、内膜与中膜面积比、新生内膜覆盖率、~3H-TdR参入量.证明雷公藤多甙能显著抑制受损动脉内膜增生(P<0.001),而藻酸双酯钠则无此作用.
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| 关 键 词： | 血管内膜 增生 雷公藤多甙 藻酸双酯钠 |
Effect of Tripterygtam wilfordii Glycosides and poly saccharide sulphate on the intimal proliferation of injured rat aorta |
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| Wang Renpeng,Zhu Guoying,Wang Lihui. Cardiovascular Department,First Hospital,Beijing Medical University,Beijing. Effect of Tripterygtam wilfordii Glycosides and poly saccharide sulphate on the intimal proliferation of injured rat aorta[J]. Chinese Journal of Interventional Cardiology, 1996, 0(4) |
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| Authors: | Wang Renpeng Zhu Guoying Wang Lihui. Cardiovascular Department First Hospital Beijing Medical University Beijing |
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| Affiliation: | Wang Renpeng,Zhu Guoying,Wang Lihui. Cardiovascular Department,First Hospital,Beijing Medical University,Beijing 100034 |
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| Abstract: | 31 rat were divided randomly into control group (n=10),tripterygium wilfordii glycosides group (n = 10 9. 4 mg/kg per day),and poly saccharide sulphate group (n=11. 30 mg/per day). We made balloon endothelium denudation in thoracic aortae of the rats. The treatments with drugs began 6 days before balloon injury and continously until the animal were killed 14 day after balloon injury. The determinations for area of neointima, neointima /media, coverage of neointima and 3H-TdR incoperation of thoracic aortae suggested that tripterygium wilfordii glycosides can inhibit intimal proliferation of injuried aorta, whill poly saccharide sulphate shows no effect. |
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| Keywords: | Intima Proliferation Tripterygium wilfordii glycosides Poly saccharide sulphate |
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