|
|||||
|
|
Increased Osteopontin-Positive Macrophage Expression in Colorectal Cancer Stroma with Synchronous Liver Metastasis |
|
| Authors: | Motohiro Imano Kiyokata Okuno Tatsuki Itoh Eizaburo Ishimaru Takao Satou Hitoshi Shiozaki |
| Institution: | (1) Department of Surgery, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama Osaka, 589-6511, Japan;(2) Ambulatory Treatment Center, Kinki University Hospital, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, Japan;(3) Department of Pathology, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Japan |
| Abstract: | BackgroundThe macrophages that infiltrate the tumor stroma are termed tumor-associated macrophages (TAMs). TAMs contribute to hematogenous spread of cancer cells especially liver metastasis. Osteopontin (OPN) is also related to tumor metastasis and proliferation of tumors. OPN is mainly expressed in macrophages of stroma other than that of tumor cells. The aim of the present study was to investigate differences in OPN-positive TAMs between cases of colorectal cancer with synchronous liver metastasis and those without liver metastasis. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |