| 微小RNA与肿瘤浸润转移 |
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| 引用本文： | 李俊.微小RNA与肿瘤浸润转移[J].国际肿瘤学杂志,2010,37(2). |
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| 作者姓名： | 李俊 |
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| 作者单位： | 复旦大学附属妇产科医院妇科,200011 |
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| 摘 要： | 微小RNA(miRNA)在多数肿瘤中存在异常表达,能在转录后水平调控靶基因的表达,发挥促进或抑制肿瘤浸润转移的作用,其自身的表达也受表观遗传学静息等多种机制的调节.miRNA作为一种理想的标记物,有望成为临床肿瘤治疗的新靶点.
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| 关 键 词： | 微小RNA 肿瘤 肿瘤浸润 肿瘤转移 |
MicroRNA's function in neoplasm invasiveness and metastasis |
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| Abstract: | MicroRNA( miRNA) is expressed in most malignant tumors. MiRNA plays important roles in promoting or inhibiting tumor invasion and metastasis through regulating specific gene expression posttranscrip-tionlly. Deregulation of miRNA can be attributed to multiple mechanisms, such as epigenetic silencing. As an i-deal biomarker, miRNA might be a useful therapeutic target in treatment of malignancies clinically. |
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| Keywords: | MicroRNA Neoplasms Neoplasm invasiveness Neoplasm metastasis |
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