肝细胞癌CT表现与手术病理对照及其与血管内皮生长因子表达的关系

目的：探讨肝细胞癌(HCC)的 CT 表现与手术病理对照及其与血管内皮生长因子(VEGF)表达的关系,为治疗提供依据。方法收集75例 HCC 患者资料,术前行 CT 平扫及增强扫描,术后对病理标本进行石蜡包埋、组织切片,常规 HE 染色,并采用免疫组织化学染色 S-P 法,检测其 VEGF 蛋白的表达。将 HCC 的 CT 表现与手术病理进行对照,并统计分析 CT 所见与 VEGF表达的关系。结果①75例 HCC 患者,术前 CT 所表现的肝硬化和淋巴结肿大与手术病理所见差异有统计学意义(P <0.05);而HCC 的肿瘤长径、门静脉或肝静脉癌栓的 CT 表现与手术病理所见相似,差异无统计学意义(P >0.05)。②HCC 的假包膜、肿瘤长径、病理血管、瘤内坏死与 VEGF 表达之间差异有统计学意义(P <0.05);HCC 的门静脉或肝静脉癌栓、肝硬化、肝内病灶(单发或多发)、淋巴结肿大与 VEGF 表达之间差异无统计学意义(P >0.05)。结论 HCC 的 CT 表现与 VEGF 表达密切相关,CT 征象虽然可以大部分反映 HCC 的病理及生物学特性,仍有一定的局限性。

Comparison of CT performance of hepatocellular carcinoma with postoperative pathology and its relationship with vascular endothelial growth factor

Objective To compare CT performance of the hepatocellular carcinoma (HCC)with postoperative pathology and to probe their relationships with vascular endothelial growth factor (VEGF)expression in order to provide more information for the treatment.Methods Clinical data of 75 patients with HCC were enrolled,including preoperative plain and enhanced CT scans,post-operative results of HE staining and immunohistochemical one of VEGF.The CT manifestations were compared with the pathological results of the HCC,and the relationship of CT findings and the VEGF expression was anlyzed.Results There was significant differ-ence between the liver cirrhosis or lymph node enlargement on CT in 75 patients with HCC and the pathology (P <0.05);However the tumor diameter,tumor emboli of portal vein and hepatic vein on CT were similar to those in pathology,exhibiting no statistically significant difference (P >0.05).The psuedocapsule of HCC,tumor size,pathological blood vessel,and tumor necrosis were related with the VEGF expression (P <0.05);However the tumor emboli of portal vein and hepatic vein,cirrhosis of the liver and intrahe-patic lesions (single or multiple)and lymph node enlargement were not related with VEGF expression (P >0.05).Conclusion The CT manifestations of HCC are closely related to the expression of VEGF.CT may reflect the pathological and biological characteris-tics of HCC with some limitations.