| Nav1.6在口腔黏膜白斑及口腔鳞癌中的表达 |
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| 引用本文： | 蔡伯惠,祝心威,王润,蒋勇.Nav1.6在口腔黏膜白斑及口腔鳞癌中的表达[J].实用口腔医学杂志,2016(5):670-673. |
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| 作者姓名： | 蔡伯惠 祝心威 王润 蒋勇 |
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| 作者单位： | 230032 合肥,安徽医科大学口腔医学院·口腔医院口腔预防教研室,安徽省口腔疾病研究中心实验室 |
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| 基金项目： | 安徽省自然科学基金(1508085MH187) |
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| 摘 要： | 目的:探讨钠离子通道Nav1.6在口腔黏膜白斑及口腔鳞癌中的表达及意义.方法:采用免疫组化SP法及Westernblot法检测Nav1.6在口腔正常组织(21例)、白斑(32例)及口腔鳞癌组织(63例)中的表达情况.结果:免疫组化检测,Nav1.6在正常组、口腔白斑组以及癌症组中的阳性表达率分别为6.25％、40％、76.74％;Nav1.6的表达与口腔鳞癌的病理分期有关.Western blot检测,正常组、口腔白斑组、癌症组中Nav1.6的蛋白表达量分别为:0.469±0.015、0.545±0.016、0.848 ±0.020(P ＜0.05).结论:Nav1.6在口腔黏膜癌前病变及口腔鳞状细胞癌的发生和发展中可能起到了一定的作用.
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| 关 键 词： | Nav1.6 口腔黏膜白斑 口腔鳞状细胞癌 |
Expression of Nav1.6 in oral leukoplakia and oral squamous cell carcinoma |
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| Abstract: | Objective:To study the expression and significance of sodium channel Nav1.6 in oral leukoplakia and squamous cell carcinoma.Methods:Immunohistochemistry and Western blot were used to detect the expression of Nav1.6 in 21 case of normal oral mucosa,32 of oral leukoplakia and 63 of oral squamous cell carcinoma(OSCC).Results:Immunohistochemical results showed that the positive rate of Nay1.6 in normal group,oral leukoplakia group and OSCC group was 6.25％,40％ and 76.74％ respectively.The expression of Nav1.6 was related to the differentiation of oral squamous cell carcinoma.Western blot results revealed that the content of Nav1.6 in normal oral mucosa,oral leukoplakia and OSCC was 0.469 ±0.015,0.545 ±0.016 and 0.848 ±0.020(P ＜0.05) respectively.Conclusion:Nay1.6 may play a role in the development of OSCC. |
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| Keywords: | Nav1 6 Oral leukoplakia Oral squamous cell carcinoma(OSCC) |
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