125I放射粒子植入治疗颌面部性恶性肿瘤43例疗效分析

目的：观察125I放射粒子植入治疗颌面部恶性肿瘤的临床效果及患者生存率。方法：纳入颌面部恶性肿瘤的患者43例,按治疗计划系统（TPS）植入125I粒子,粒子间距1cm,活度0．7mCi,术后随访复查。结果：粒子植入顺利,平均41颗／人,术后未见粒子移位。随访率93．02％,治疗有效率（PR＋CR）90．70％,靶区未见瘤复发,因瘤死亡率9．30％。患者总生存率74．43％,0．5、1、2、3年及5年累积患者生存率分别为：93．0％、85．7％、79．3、69．8％及56．9％,平均生存36．06～50．04个月,中位生存期43．05月,最长无瘤生存60月,1级放射损伤率20．93％,2例患者原有面神经损伤术后恢复。结论：125I粒子植入治疗颌面部恶性肿瘤组织损伤小,能提高患者生存率并保证口咽功能。

The efficacy of 125I radio active particle implantation in the treatment of maxillofacial malignancy of 43 cases

Objective:To investigate the effects of 125I radioactive particle implantation in the treatment of maxillofacial malignancy. Methods:43 patients with maxillofacial malignancy were treated with 125I radioactive particle implantation.The procedure was carried out according to the treatment planning system(TPS),with the particles spaced uniformly at 1 cm intervals and with the activity of 0.7 m Ciby 41 particles per case on a verage.All patients were followed up for 6-60 months.Results:The whole treatment procedurewas successful,and no particle displaced.The follow-up rate was 93.02% and treatment effective rate(CR+PR) was 90.70%.Norecur-rence was foundinall target areas.The mortality due to tumor was 9.30%and total survival rate was 74.43%.The cumulative survival rate of the patients in 0.5,1,2,3 and 5 years was 93.0%,85.7%,79.3,69.8% and 56.9% respectively.Survival periodon aver-age was 36.06-50.04 months,with the median of 43.05 months.The longest tumor-free survival period was 60 months.Radiation in-jury rate was 20.93% and only level 1 radiation injury was observedinall the cases.Facial nerve dys function was found in 2 cases and recovered after treatment.Conclusion:Treatment of maxillofacial malignancy by implantation of 125I particles is convenient and mini-mally invasive.The treatment canincrease survival rate of the patients and guaran tee the oropharynxes' function.