男性患者血清CXCL10水平与OSAS病情的相关性研究

目的:研究男性阻塞性睡眠呼吸暂停综合征(OSAS)患者血清CXCL10水平与OSAS病情的相关性.方法:纳入将52名男性OSAS患者与41名对照组受试者.通过多导睡眠监测评价每名受试者整夜睡眠中的低通气指数(AHI),ELISA法测定血清CXCL10.对血清CXCL10水平与OSAS病情进行相关性分析.结果:OSAS组与对照组血清CXCL10水平(ng/ml)分别为99.18(70.46-158.01)和64.13(53.5-73.6) (P ＜0.001).多元logistic回归分析表明CXCL10是OSAS患病的独立预测指标(OR:1.021;95％ CI:1.009～1.1.035;P＜0.001).轻度和中度OSAS患者血清CXCL10水平(ng/ml)分别为82.7 (56.76 ～145.51)和113.28(87.15 ～162.67).受试者血清CXCL10水平与AHI指数具有独立相关性(r=0.476,P＜0.001).结论:血清CXCL10水平与OSAS患病及病情独立相关,血清CXCL10水平可能是诊断OSAS和评价病情的生物学指标.

The correlation between serum CXCL10 level and the severity of OSAS in male patients

Objective:To investigate the correlation between serum CXCL10 level and the severity of obstructive sleep apnea syndrome(OSAS) in male patients.Methods:52 male patients and 41 control volunteers were enrolled.Polysomnography was processed to monitor the AHI scores.Serum CXCL10 level was determined by ELISA.The correlation between serum CXCL10 level and AHI scores was analyzed statistically.Results:Serum CXCL10 level(ng/ml) in the OSAS groups was significantly higher than that in the control group [99.18 (70.46-158.01) vs 64.13 (53.5-73.6),P ＜ 0.001].Multivariate logistic regression analysis demonstrated that serum CXCL10 level was the only independent predictor of OSAS(OR:1.021;95％ CI:1.009-1.035;P ＜0.001).The serum CXCL10 level was positively correlated with the severity of OSAS [CXCL10 level in mild OSAS:82.7 (56.76-145.51);in moderate:OSAS 113.28 (87.15-162.67)].Serum CXCL10 level was independently correlated with AHI scores(r =0.476,P ＜ 0.001).Conclusion:Serum CXCL10 level was independently associated with the occurrence and the severity of OSAS.Serum CXCL10 level can be used as a biomarker to diagnose the OSAS and further to assess the severity of OSAS.