咪唑安定与异丙酚在经阴道取卵术中的比较

目的：比较咪唑安定联合芬太尼与异丙酚联合芬太尼作为清醒麻醉在经阴道无痛取卵术中应用效果和安全性。方法：将80例体外受精一胚胎移植患者随机分为咪唑安定联合芬太尼组（咪唑安定组，n=40）和异丙酚联合芬太尼组（异丙酚组，n=40），在保持镇静程度相当的前提下观察两组在取卵术中镇痛效果，循环系统变化（血压和心率），呼吸变化（呼吸频率、指测血氧饱和度和呼吸抑制发生率），以及术后遗忘、恶心呕吐不良反应。结果：两组镇痛效果、循环系统变化无差异。咪唑安定组的呼吸抑制、术后呕吐发生率和术后遗忘率分别为5．0％、10．0％和25．0％，异丙酚组分别为25．0％、27．5％和7．5％，两组具有显著性差异（P〈0．05）。结论：无痛阴道取卵术的清醒麻醉方案中，咪唑安定联合芬太尼的副作用较异丙酚联合芬太尼少。

Comparison of midazolam and propofol as conscious sedation in oocyte retrieval of IVE-ET

OBJECTIVE: To compare the efficacy and safety of midazolam combined with fentanyl and propofol combined with fentanyl as conscious sedation in oocyte retrieval of in vitro fertilization and embryo transplantation (IVF-ET). METHODS: Eighty patients receiving IVE-ET were randomly divided into midazolam combined with fentanyl group (midazolam group) and propofol combined with fentanyl group (propofol group). Antalgic effects, circulation status (blood pressure, heart rate), respiration status (rate, oxygen saturation and respiration depression) during operation, nausea and vomiting, and amnestic effects after operation were compared. RESULT: No differences of antalgic effects and circulation status between two groups were observed. Percentages of respiration depression,vomiting and amnesia of midazolam group were 5.0 %, 10.0 % and 25%, respectively, and those of propofol group were 25%, 27.5% and 7.5%, respectively, which had statistical significance. CONCLUSION: As conscious sedation, midazolam combined with fentanyl is better than propofol combined with fentanyl in oocyte retrieval of IVF-ET.