Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients. |
| |
| Authors: | Joseph Meletiadis Thomas J Walsh Eun Hwa Choi Peter G Pappas David Ennis Jeffrey Douglas George A Pankey Robert A Larsen Richard J Hamill Stephen Chanock |
| |
| Institution: | National Cancer Institute, Bethesda, MD, USA. |
| |
| Abstract: | A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians. |
| |
| Keywords: | |
|
|
