遗传因素对高血压病人群靶器官损害发生的影响

目的探讨血管紧张素Ⅱ1型受体(AT1R)A／C1166多态性、纤溶酶原激活物抑制剂-1(PAl-1)4G／5G多态性与高血压病人群肾脏损害(RD)和脑梗死(CI)发生的关系。方法以高血压病人群为随机研究对象，采用等位基因特异性寡核苷酸探针杂交法分析AT1R基因型和PAI-1基因型。结果(1)AT1R基因型与肾脏功能显著相关，AC基因型肾脏功能显著差于AA基因型，PM-1基因型与肾脏功能无显著性关系；(2)AT1R基因型与CI发生无显著性关系；CI阳性与CI阴性高血压病人群相比，PAI-1基因型分布有显著性差异，前者4G／4G基因型频率显著高于后者。结论AT1RAC基因型和PM-14G／4G基因型分别为高血压病人群RD和CI的危险因素。

Effect of genetic factors on target organ damage in patients with essential hypertension

Objective To investigate the influences of angiotensin Ⅱ type 1 receptor(AT1 R)A/C 1166 polyMorphism and plasmino-gen actvator inhibitor－1 (PAI－1) 4G/5G polymorphism on the development of renal damage(RD) and cerebral infarction(CI) in pa-tients with essential hypertension(EH) .Methods The patients with EH were randomly enrolled in the study. ATiR and PAI－1genotypeswere analyzed by the allele specific oligonucleotide hybridization technique. Results 1. AT1R genotypes were significantly related to renalfunction,with renal function in AC genotype worse than that in AA genotype. PAI- 1 genotypes were not signiticantly associated with renalfunction;2.AT1R genotypes were not significantly associated with CI. There was a significant difference in PAI－1 genotypes distributionbetween the patients with CI and the patients without CI, with the 4G/4G genotype frequency in the former higher compared to that in thelater. Conclusion AT1R AC genotype and PAI－1 4G/4G genotype are risk factors for RD and CI in population with EH,respectively