百合知母汤的化学成分研究(Ⅰ)

目的研究百合知母汤水煎液中的化学成分,为探讨其药效物质基础提供依据。方法采用硅胶柱反复色谱分离化合物,并通过理化数据和波谱数据确定其结构。结果从百合知母汤水煎液的二氯甲烷和醋酸乙酯萃取部分共分得9个化合物,分别鉴定为棕榈酸(hexadecanoic acid,1)、5-羟甲基糠醛(5-hydroxymethyl-2-furalde-hyde,2)、豆甾醇(stigmasterol,3)、对羟基苯甲醛(p-hydroxybenzaldehyde,4)、对羟基桂皮酸(p-hydroxycinnamicacid,5)、2,3,4′-三羟基-4-甲氧基二苯甲酮(2,3,4′-trihydroxy-4-methoxybenzophenone,6)、知母皂苷AⅢ(timosa-poninAⅢ,7)、芒果苷(mangiferin,8)、β-胡萝卜苷(β-daucosterol,9)。结论以上化合物均为首次从百合知母汤中分得,其中化合物6为首次公开报道的天然产物;化合物5首次在组成百合知母汤的单味药百合和知母中发现,可能为百合知母汤水煎液新产生的化学成分。

Chemical constituents of Baihe Zhimu Decoction

Objective To study the chemical constituents of Baihe Zhimu Decoction. Methods Silica gel column chromatography was used to isolate and purify the compounds, and the structures were identified on the basis of IR, MS, ~1 H-NMR, ~(13)C-NMR, and other data. Results Nine compounds were isolated and identified as hexadecanoic acid (1) , 5-hydroxymethyl-2-furaldehyde (2), stigmasterol (3) , p-hydroxy-benzaldehyde (4), p-hydroxycinnamic acid (5), 2, 3, 4'-trihydroxy-4-methoxybenzophenone (6), timosa-ponin AIII (7), mangiferin (8), and β-daucosterol (9). Conclusion These compounds are isolated from Baihe Zhimu Decoction for the first time. Compound 6 is firstly reported as a new natural product.