Sarcoidosis occurring after interferon-alpha therapy for chronic hepatitis C: report of two cases |
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Authors: | Hirano Atsushi Kataoka Mikio Nakata Yasunari Takeda Katsuyuki Kamao Takayuki Hiramatsu Junichi Kimura Goro Tanimoto Yasushi Kanehiro Arihiko Tanimoto Mitsune |
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Institution: | Department of Internal Medicine II, Okayama University Medical School, Okayama, Japan. ka-hirano@mug.biglobe.ne.jp |
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Abstract: | We report two patients who were diagnosed with sarcoidosis after receiving interferon (IFN)-alpha therapy for chronic hepatitis C, and conduct a review the relevant literature. The first patient was a 52-year-old female who developed multiple subcutaneous nodules 2 months after finishing IFN-alpha therapy. A skin biopsy from subcutaneous nodules on the right elbow joint revealed sarcoid granulomata. These lesions resolved spontaneously 4 months later. The second patient, a 57-year-old male, developed bilateral hilar and mediastinal lymph node enlargement 2 years after finishing IFN-alpha 2a therapy. A transbronchial lung biopsy demonstrated sarcoid granulomata. In addition, he had uveitis and left ulnar nerve involvement. His eye and nerve involvement gradually improved over 20 months. It is feasible that IFN therapy has been a trigger for sarcoidosis in these patients. |
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Keywords: | chronic hepatitis C granuloma interferon-α sarcoidosis |
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