野菊花挥发油抗炎镇痛作用

目的:研究野菊花挥发油抗炎镇痛的药理活性。方法:取昆明种小鼠,随机分成正常组,模型组,阿司匹林组(0.5 g·kg-1),野菊花挥发油高、中、低剂量组(0.8,0.4,0.2 g·kg-1)。应用小鼠耳肿胀、足肿胀及棉球肉芽肿等实验评价野菊花挥发油的抗炎活性,采用热板法、扭体法实验考察野菊花挥发油的镇痛作用。结果:与正常组比较,模型组小鼠耳肿胀明显,小鼠棉球肉芽肿明显,小鼠足趾肿胀明显,扭体次数明显增加,均具有明显的统计学差异(P0.05);与模型组比较,野菊花挥发油高、中、低剂量对二甲苯致小鼠耳肿胀、棉球肉芽肿、角叉菜胶致足肿胀均有明显的抑制作用,并能明显减少小鼠的扭体次数,均具有明显的统计学差异(P0.05)。另外给药后,与正常组比较,野菊花挥发油高、中、低剂量均能明显提高小鼠痛阈值(P0.05)。结论:野菊花挥发油有较强的抗炎镇痛活性。

Anti-inflammatory and Analgesic Effects of Essential Oil from Chrysanthemi Indici Flos

Objective: To investigate the anti-inflammatory and analgesic effect of essential oil from Chrysanthemi Indici Flos (EOCIF). Method: Totally 60 KM mice were divided into six groups, i.e. the normal group, the model group, the aspirin group (0.5 g · kg^-1), EOCIF high, middle and low dose groups (0.8, 0.4, 0.2 g · kg^-1). Auricle edema induced by dimethylbenzene, cotton pellet granuloma of the mice and foot edema induced by carrageen were used to detect the anti-inflammatory activity. Acetic acid writhing method and hot-plate method were used to study the analgesic activity. Result: Compared with the normal group, the model group showed notable auricle edema and cotton pellet granuloma and significant increase in writhing frequency, with significant statistical difference (P <0.05). Compared with the model group, EOCIF high, middle and low dose groups showed obvious inhibitory effects in dimethylbenzene-induced auricle edema, cotton pellet granuloma and carrageen-induced foot edema and significant decrease in writhing frequency, with significant statistical difference (P <0.05). Besides, after the administration, compared with the model group, EOCIF high, middle and low dose groups showed obvious increase in pain threshold in mice (P <0.05). Conclusion: The EOCIF Chrysanthemi Indici Flos shows stronger anti-inflammatory and analgesic activities.