| 加味四逆散对肠易激综合征大鼠不同脑区核团c-fos蛋白表达的影响 |
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| 引用本文： | 白霞,谢小磊,李梦,耿建国,李冬华,杜宇琼. 加味四逆散对肠易激综合征大鼠不同脑区核团c-fos蛋白表达的影响[J]. 中国中医基础医学杂志, 2010, 0(1) |
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| 作者姓名： | 白霞 谢小磊 李梦 耿建国 李冬华 杜宇琼 |
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| 作者单位： | 首都医科大学中医药学院; |
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| 基金项目： | 国家中医药管理局中医药科学技术研究专项资助项目(06-07ZQ01) |
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| 摘 要： | 目的:观察加味四逆散对肠易激综合征大鼠不同脑区核团c-fos蛋白表达的影响。方法:采用束缚制动加灌服番泻叶改良的方法制备肠易激综合征大鼠模型,将24只W istar大鼠随机分成正常组、模型对照组、加味四逆散组和得舒特组,用免疫组织化学法检测大鼠大脑皮质和纹状体c-fos阳性神经元的变化。结果:加味四逆散可明显降低大鼠脑皮质和纹状体c-fos阳性神经元的数目。结论:加味四逆散能够降低c-fos在IBS大鼠不同脑区核团的蛋白表达,干预脑肠轴紊乱的调控机制。
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| 关 键 词： | 加味四逆散 肠易激综合征 c-fos蛋白表达 |
Effects of JiaWei Sini Power on Expression of c-fos in Different Brain Areas and Nucleus of Rats with Irritable Bowel Syndrome |
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| Abstract: | Objective:To observe the effect of Jiawei Sini Dection on expression of c-fos protein in different brain areas in rats of irritable bowel syndrome (IBS).Method:The rat model of irritable bowel syndrome was made by binding stress with taking senna decoction,Twenty-four Wistar rats were divided randomly into normal group,model group,Jaiwei sinisan group and Dicetel group.The change in the number of c-fos positive neurons were detected by immunohistochemistry in rat cortex and striatum.Results:Jiawei Sini Deco... |
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| Keywords: | Jiawei Sini Decoction Irritable bowel syndrome Expression of c-fos Protein |
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