Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L |
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| Authors: | Dae Yong Kim Gwan Ui Hong Jai Youl Ro |
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| Institution: | (1) Department of Pharmacology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 300 chunchun-dong, Jangan-ku, Suwon, 440-746, South Korea |
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| Abstract: | Background Astrocytes, which play an active role in chronic inflammatory diseases like multiple sclerosis, exist close to mast cells
with which they share perivascular localization. We previously demonstrated the possibility that astrocytes and mast cells
interact in vitro and in vivo. This study aimed to investigate the signaling pathways and the role for astrocytes in the interaction
of astrocytes and mast cells. |
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