Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer |
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| Authors: | Callinice D Capo-chichi Kathy Q Cai Fiona Simpkins Parvin Ganjei-Azar Andrew K Godwin Xiang-Xi Xu |
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| Affiliation: | (1) Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA;(2) Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA;(3) Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA;(4) Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, FL 33136, USA;(5) Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA;(6) Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA |
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| Abstract: | Background Despite our substantial understanding of molecular mechanisms and gene mutations involved in cancer, the technical approaches for diagnosis and prognosis of cancer are limited. In routine clinical diagnosis of cancer, the procedure is very basic: nuclear morphology is used as a common assessment of the degree of malignancy, and hence acts as a prognostic and predictive indicator of the disease. Furthermore, though the atypical nuclear morphology of cancer cells is believed to be a consequence of oncogenic signaling, the molecular basis remains unclear. Another common characteristic of human cancer is aneuploidy, but the causes and its role in carcinogenesis are not well established. |
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