高聚生对大肠癌根治术后患者早期免疫功能的影响

目的 :探讨围手术期使用高聚生对大肠癌根治术后患者早期免疫功能的影响。方法 :将行大肠癌根治术患者随机分为实验组 (n =2 4 )和对照组 (n =2 4 )。实验组于术前 1周开始至术后第 10天每天静脉滴注高聚生 10 0 0单位 ;对照组不使用高聚生 ,予以等量生理盐水静脉滴注。 2组患者均于术前第 3天和术后第 1、7、10天采血 ,以检测T细胞亚群及NK细胞活性和sIL 2R水平的变化。结果 :术后第 1天CD3、CD4、CD4 /CD8比值和NK细胞活性较术前显著下降 (P <0 .0 5 )。实验组术后第 7天各项指标已恢复到术前水平。术后第 10天CD3、CD4、CD4 /CD8比值及NK细胞活性较对照组及本组术前水平均有明显升高 (P <0 .0 5 )。术后 10d实验组sIL 2R水平较对照组下降明显 (P <0 .0 5 )。结论 :大肠癌患者术后早期免疫功能低下 ,应用高聚生可明显减轻大肠癌术后细胞免疫抑制程度 ,提高细胞免疫功能

Effects of Staphylococcin Aureus on the Early Alterations of Immunity in Patients with Colon Cancer Undergoing Radical Operation

Objective:To study the effects of perioperative administration of staphylococcin aureus on the early immune function of patients with colorectal cancer undergoing radical operation.Methods:Forty-eight patients were randomly divided into experimental group( n =24),and control group( n =24).In experimental group,1000u of staphylococcin aureus was administered daily,from a week before operation till postoperative day 10;In control group, normal saline was administered daily.T lymphocyte subsets,NK cell activity and sIL 2R levels in patients of both groups were assayed on day 3 preoperative,and on day 1,day 7 and day 10 after operation,respectively.Results:At 1 day after operation,CD3,CD4,CD4/CD8 ratio decreased more significantly than those before operation( P <0.05).All above parameters in experimental group resumed to preoperative levels on postoperative day 7.CD3,CD4,CD4/CD8 ratio and NK cell activity in staphylococcin aureus treated patients on postoperative day 10 significantly increased when compared with those in controls as well as that of before operation( P <0.05).At 10 days after operation,sIL 2R levels decreased more rapidly in experimental group than in control group( P < 0.05 ).Conclusion:The early immune function of patients with colorectal cancer was deficient after operation,the use of staphylococcin aureus could significantly alleviated the patient's negative immune reaction perioperatively, and improved cell immune function.