| 大戟配伍大枣减毒相关化学物质的初步研究 |
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| 引用本文： | 徐丽,尚尔鑫,沈祥春,时乐,段金廒,徐立.大戟配伍大枣减毒相关化学物质的初步研究[J].安徽医药,2010,14(7):758-760. |
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| 作者姓名： | 徐丽 尚尔鑫 沈祥春 时乐 段金廒 徐立 |
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| 作者单位： | 南京中医药大学药学院,江苏,南京,210046;南京中医药大学江苏省方剂基础与应用重点实验室,江苏,南京,210046;贵阳医学院药理研究室,贵州,贵阳,550004 |
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| 摘 要： | 目的初步探讨大戟毒副作用物质基础及大枣解毒减毒作用的机制。方法利用大鼠在体小肠灌流技术,UPLC-MASS测定大戟95%醇提物,大戟95%醇提物与大枣水提物混合溶液随灌流时间的变化。结果各色谱峰在大戟95%醇提物中随灌流时间呈现不同的变化,主要变化趋势有四种,表现为峰型的增大、减少,及配伍大枣后峰型的消失。结论本方法排除了部分与解毒减毒作用无关的成分,将发生变化的成分归类,缩小了寻找毒性成分的范围,降低了盲目性,为更深层次的研究奠定了基础。
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| 关 键 词： | 大戟 在体小肠灌流 高效液相色谱 |
The preliminary study of the related detoxification chemical for the compatibility between euphorbia and jujube |
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| XU Li,SHANG Er-xing,XU Xiang-chun,SHI Le,DUAN Jin-ao,XU-li.The preliminary study of the related detoxification chemical for the compatibility between euphorbia and jujube[J].Anhui Medical and Pharmaceutical Journal,2010,14(7):758-760. |
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| Authors: | XU Li SHANG Er-xing XU Xiang-chun SHI Le DUAN Jin-ao XU-li |
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| Abstract: | Aim To study the material basis of toxicity in euphorbia and detoxification mechanism for the compatibility of Jujube.Methods In vivo intestinal perfusion was carried out in rats.The changes of the euphorbia solution and the euphorbia jujube mixed solution with the perfusion time were determined by UPLC-MASS.Results Euphorbia solution and the mixed solution in the MassLynx software for metabolomics scores chart shows a clear distinction.Euphorbia solution changed in the process of the perfusion,mainly for p... |
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| Keywords: | euphorbia in vivo intestinal perfusion HPLC |
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