Utility of a New Bolus-Injectable Nanoparticle for Clinical Cancer Staging |
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Authors: | Mukesh Harisinghani Robert W Ross Alexander R Guimaraes Ralph Weissleder |
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Affiliation: | *Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA;†Harvard Cancer Center, Boston, MA, USA;‡Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA |
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Abstract: | BackgroundIn this study, we report on the use of a new, bolus-injectable, carboxymethyl dextran-based magnetic nanoparticle (MNP), ferumoxytol, to improve detection in loco-regional lymph nodes by magnetic resonance imaging (MRI).MethodsThis preliminary study was performed as a prospective, single-center, open label pilot study to determine the magnitude of nodal MRI signal changes and to determine the optimal time points for imaging following intravenous (IV) bolus injection of the MNP. The study group consisted of 10 patients, all of whom were diagnosed with prostate cancer before any systemic therapy.ResultsAll 10 patients had lymph nodes evaluated by histopathology. Of the evaluated 26 lymph nodes, 20 were benign and 6 were malignant. The mean short-axis diameter of benign lymph nodes was 6 mm and the mean short-axis diameter of malignant lymph nodes was 7 mm. Following IV administration, there was a significant change in mean signal-to-noise ratio (SNR) of benign lymph nodes (P < .0001) whereas there was little change in the mean SNR of malignant nodes (P = .1624). No adverse events were encountered.ConclusionFerumoxytol is safe and, at the appropriate circulation interval, modulates nodal signal intensity, allowing for identification of malignant nodal involvement by MRI. |
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Keywords: | Nanoparticle MRI ferumoxytol prostate cancer lymph nodes |
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