Isolation and identification of a novel human metabolite of cyclosporin A: dihydro-CsA M17 |
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| Authors: | G P Meier S B Park G C Yee D J Gmur |
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| Affiliation: | Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle 98195. |
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| Abstract: | A novel metabolite of cyclosporin A was observed in human blood and urine. An analytical sample of this metabolite was isolated from human urine and the structure was determined to be (8-hydroxy-6,7-dihydro-MeBMT1) cyclosporin based on the 1H-NMR, 13C-NMR, FAB-MS, and HPLC characteristics of the biological sample as well as by comparison with a synthetically derived authentic sample. The significance of this metabolite in terms of the pathway by which cyclosporin A is metabolized is discussed. |
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