| 4%与1%吲哚美辛乳膏的镇痛抗炎作用比较 |
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| 引用本文： | 李艳春,马恩龙,王敏伟. 4%与1%吲哚美辛乳膏的镇痛抗炎作用比较[J]. 中国医院药学杂志, 2004, 24(10): 626-627 |
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| 作者姓名： | 李艳春 马恩龙 王敏伟 |
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| 作者单位： | 沈阳药科大学药理教研室,辽宁,沈阳,110016 |
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| 摘 要： | 目的:观察4%与1%吲哚美辛乳膏的镇痛抗炎作用.方法:以1%吲哚美辛乳膏为对比,对几种炎症、疼痛模型考察4%吲哚美辛乳膏的治疗作用.结果:4%吲哚美辛乳膏对甲醛致小鼠足部疼痛、热板法致小鼠足部疼痛、大鼠尾部压痛均有明显镇痛效果,对卡拉胶致大鼠足肿胀和二甲致小鼠耳肿胀有明显抗炎效果.结论:4%吲哚美辛乳膏具有明显的镇痛抗炎药效,优于1%吲哚美辛乳膏.
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| 关 键 词： | 镇痛 抗炎 吲哚美辛乳膏 |
| 文章编号： | 1001-5213(2004)10-0626-02 |
| 修稿时间： | 2003-11-29 |
Studies on the analgesic and anti-inflammatory effects of the 4%-indomethacin cream and 1%-indomethacin cream |
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| LI Yan-chun,MA En-long,WANG Min-wei. Studies on the analgesic and anti-inflammatory effects of the 4%-indomethacin cream and 1%-indomethacin cream[J]. Chinese Journal of Hospital Pharmacy, 2004, 24(10): 626-627 |
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| Authors: | LI Yan-chun MA En-long WANG Min-wei |
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| Abstract: | OBJECTIVE Comparison of Analgesic and anti-inflammatory effect between 4%-indomethacin and 1%-indomethacin cream was studied.METHODS Different pain and inflammation models were made to investigate effects of the 1% and 4%-indomethacin cream.RESULTS 4%-indomethacin cream produced obvious analgesic effects on pain models induced by methanal, pressing tail and heat plate. Anti-inflammatory experiments results showed that ear edema resulted from dimethyl benzene and paw edema induced by carragheenin were significantly inhibited by 4%-indomethacin cream.CONCLUSION 4%-indomethacin cream has significant analgesic and anti-inflammatory effect, and is better than 1%-indomethacin cream. |
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| Keywords: | analgesic effects anti-inflammatory effects indomethacin cream |
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