| 三氯乙烯染毒小鼠骨髓微核试验观察 |
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| 引用本文： | 黄海雄,张锦周,黄钰,庄志雄,张炳尧,慈捷元.三氯乙烯染毒小鼠骨髓微核试验观察[J].职业与健康,2002,18(4):35-36. |
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| 作者姓名： | 黄海雄 张锦周 黄钰 庄志雄 张炳尧 慈捷元 |
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| 作者单位： | 广东省深圳市卫生防疫站,518020 |
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| 摘 要： | 目的 检测三氯乙烯对受试动物致突变作用。方法 以不同剂量的三氯乙烯染毒实验动物,经口灌胃给予受试物,用30h给受试物法,即两次给受试物间隙24h,第2日给受试物后6h处死动物,制片,观察并计数嗜多染红细胞的微核率,并与阳性对照组和阴性对照组进行比较分析。结果 与阴性对照组相比,各剂量组的微核率差异无显著性(P>0.05)结论 三氯乙烯小鼠骨髓嗜多染红细胞微核试验结果阴性。
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| 关 键 词： | 三氯乙烯 嗜多染红细胞 微核 |
| 文章编号： | 1004-1257(2002)04-0035-02 |
| 修稿时间： | 2001年5月12日 |
Observation on the bone barrow micro - nuclear experiment on the trichloroethylene- infected mice |
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| HUANG Haixiong,ZHANG Jinzhou.Observation on the bone barrow micro - nuclear experiment on the trichloroethylene- infected mice[J].Occupation and Health,2002,18(4):35-36. |
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| Authors: | HUANG Haixiong ZHANG Jinzhou |
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| Abstract: | Objective] To investigate mutational function of trichloroethylene(TCE) on the mice. Methods] The mice were divided into five groups including a positive group, a negative group and three poisoning groups. The mice received TCE twice through gavage by 30h method (24 hrs' interval between 2 times) . Sliders were made, polychromatic erythrocyte ( PCE) was observed and rates of their micronucleus were counted and were compared with positive and negative group respectively. Results] Compared with the negative group, no significant difference was found in micronucleus. ( P > 0.05) Conclusion] TCE couldn't promote rates of micronucleus of PCE in |
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| Keywords: | trichloroethylene(TCE) polychromatic erythrocyte (PCE) micronucleus |
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