| 心肌营养素-1与糖尿病心肌病 |
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| 引用本文： | 王春玲,田林红,张涛.心肌营养素-1与糖尿病心肌病[J].国际内分泌代谢杂志,2009,30(6):47-49. |
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| 作者姓名： | 王春玲 田林红 张涛 |
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| 作者单位： | 兰州大学第二医院内分泌科,730030; |
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| 基金项目： | 甘肃省科技厅-技术研究与开发专项计划资助项目 |
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| 摘 要： | 心肌营养素-1(CT-1)是从小鼠胚胎干细胞中克隆出的一种细胞因子,为白细胞介素石细胞因子家族的新成员.CT-1可通过促进心肌细胞肥大、成纤维细胞的生长及胶原的合成,参与和调节心室肥厚及重构.糖尿病心肌病的病理生理过程中存在心肌重构,且2型糖尿病患者血浆中CT-1水平升高,表明CT-1可能在糖尿病心肌病的发生、发展中起重要的调节作用.确切的机制尚不清楚,可能与促进心肌重构有关.
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| 关 键 词： | 心肌营养素-1 糖尿病心肌病 心室重构 血管紧张素Ⅱ Angiotensin Ⅱ |
Cardiotrophin-1 and diabetic cardiomyopathy |
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| WANG Chun-ling,TIAN Lin-hong,ZHANG Tao.Cardiotrophin-1 and diabetic cardiomyopathy[J].International JOurnal of Endocrinology and Metabolism,2009,30(6):47-49. |
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| Authors: | WANG Chun-ling TIAN Lin-hong ZHANG Tao |
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| Abstract: | Cardiotrophin-1 (CT-1) was found from the mouse embryonic stem cell clone. It is a new cytokine in interleukin-6 family. CT-1 participates in and regulates ventricular hypertrophy and ventricular re-modeling by promoting myocardial hypertrophy, the growth of fibroblasts and collagen synthesis. Cardiac re-modeling exists in the pathophysiological process of diabetic cardiomyopathy. Also the elevation of plasma CT-1 in diabetic patients indicates that CT-1 may play an important role in the regulation of diabetic cardio-myopathy. The exact mechanism is not clear yet,may be related to the promotion of cardiac remodeling. |
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| Keywords: | Cardiotrophin1IDiabetic cardiomyopathyMyocardial remodeling |
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