| 妊娠血浆蛋白-A与缺血性卒中 |
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| 引用本文： | 王永久,程焱. 妊娠血浆蛋白-A与缺血性卒中[J]. 国际脑血管病杂志, 2009, 18(9): 377-380. DOI: 10.3760/cma.j.issn.1673-4165.2010.005.012 |
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| 作者姓名： | 王永久 程焱 |
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| 作者单位： | 266100,青岛巾第八人民医院神经内科;300052,天津,天津医科大学总医院神经内科;天津医科大学总医院神经内科,天津,300052; |
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| 摘 要： | 妊娠相关血浆蛋白(pregnancy-associated plasma protein,PAPP)-A是一种高分子锌结合基质金属蛋白酶,在破裂的动脉粥样硬化斑块中高度表达.在急性冠状动脉综合征患者中,PAPP-A可作为不稳定斑块和心血管事件的新型血清生物学标记物.然而,PAPP-A在缺血性卒中的作用尚不明确.文章对PAPP-A预测缺血性卒中事件风险的价值做了综述.
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| 关 键 词： | 妊娠血浆蛋白-A 动脉粥样硬化 卒中 脑缺血 生物学标记物 |
Pregnancy-associated plasma protein-A and ischemic stroke |
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| WANG Yong-jiu,CHENG Yan. Pregnancy-associated plasma protein-A and ischemic stroke[J]. International Journal of Cerebrovascular Diseases, 2009, 18(9): 377-380. DOI: 10.3760/cma.j.issn.1673-4165.2010.005.012 |
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| Authors: | WANG Yong-jiu CHENG Yan |
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| Abstract: | Pregnancy-associated plasma protein-A (PAPP-A),a high-molecular-weight zinc-binding metrix metalloproteinase,is expressed abundantly in the ruptured atherosclerostic plaque. PAPP-A can be used as a novel biological marker of plaque instability and cardiovascular events in patients with acute coronary syndrome. However,the role of PAPP-A in iscbemic stroke remains unclear. This article reviews the value of VAPP-A in predicting the risks of ischemic stroke events. |
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| Keywords: | Pregnancy-associated plasma protein-AAtherosclerosisStrokeBrain ischemiaBiological markers |
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