| 树突状细胞及其Toll样受体与乙型肝炎慢性化研究进展 |
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| 引用本文： | 郭栋,刘秋燕. 树突状细胞及其Toll样受体与乙型肝炎慢性化研究进展[J]. 国际免疫学杂志, 2009, 33(6): 192-195. DOI: 10.3760/cma.j.issn.1673-4394.2010.03.008 |
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| 作者姓名： | 郭栋 刘秋燕 |
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| 作者单位： | 第二军医大学免疫学研究所,上海,200433; |
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| 摘 要： | 目前认为,机体对乙型肝炎病毒(HBV)的免疫耐受是乙型肝炎慢性化的主要原因.作为最重要的抗原呈递细胞,树突状细胞(DC)无论数量不足还是功能缺陷都将导致HBV在体内的持续感染.Toll样受体(TLR)是当前免疫学研究的热点,近年来,人们逐渐认识到慢性乙型肝炎(CHB)患者体内DC的TLR存在表达异常,这可能是导致乙型肝炎慢性化的一个重要原因.
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| 关 键 词： | 树突状细胞 Toll样受体 乙型肝炎 慢性化机制 |
Research progress on dendritic cells and Toll-like receptors and chronic mechanism of hepatitis B |
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| GUO Dong,LIU Qiu-yan. Research progress on dendritic cells and Toll-like receptors and chronic mechanism of hepatitis B[J]. International Journal of Immunology, 2009, 33(6): 192-195. DOI: 10.3760/cma.j.issn.1673-4394.2010.03.008 |
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| Authors: | GUO Dong LIU Qiu-yan |
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| Abstract: | Body's immune tolerance to the hepatitis B virus is considered as the main reason of chronic .Hepatitis B. Dendritic cells (DC) are the most potent professional antigen-presenting cells. The low quantity or functional defects of dendritic cells will result in persistent infection of hepatitis B virus in the body. Toll-like receptors (TLRs) is one of the immunology research hotspots in recent years. Studies have found that the abnormal expression of TLRs in patients of chronic hepatitis B may be an important reason for the persistent infection of hepatitis B virus. |
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| Keywords: | Dendritic cellsToll-like receptorsHepatitis BChronic mechanism |
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