| Na+,K+-ATP酶与脑缺血 |
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| 引用本文： | 彭文宏,徐恩. Na+,K+-ATP酶与脑缺血[J]. 国际脑血管病杂志, 2009, 18(9): 381-385. DOI: 10.3760/cma.j.issn.1673-4165.2010.005.013 |
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| 作者姓名： | 彭文宏 徐恩 |
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| 作者单位： | 广州医学院附属第二医院神经科学研究所,510260; |
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| 摘 要： | Na+,K+-ATP酶的基本功能是维持真核细胞膜内外Na+ - K+电化学梯度平衡,后者为维持细胞渗透压、调节细胞体积和维持可兴奋细胞膜静息电位所必需.Na+,K+ -ATP酶活性的维持在神经元神经递质的摄取和Ca2+外流中起着重要作用.脑缺血后,Na+,K+ -ATP酶活性降低及功能异常参与缺血性脑损伤过程.缺血预处理通过维持缺血后Na+,K+ -ATP酶活性而诱导缺血耐受.强心甾类固醇和胞二磷胆碱可通过提高Na+,K+ -ATP酶活性对脑缺血发挥神经保护效应.
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| 关 键 词： | Na-K交换ATP酶 脑缺血 缺血预处理 强心苷类 胞二磷胆碱 |
Na+ ,K+ -ATPase and cerebral ischemia |
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| PENG Wen-hong,XU En. Na+ ,K+ -ATPase and cerebral ischemia[J]. International Journal of Cerebrovascular Diseases, 2009, 18(9): 381-385. DOI: 10.3760/cma.j.issn.1673-4165.2010.005.013 |
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| Authors: | PENG Wen-hong XU En |
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| Abstract: | The basic functions of the Na+/K+ -ATPase is to maintain the balance of the Na+/K+ electrochemical gradient. The latter is indispensable for maintaining cell osmotic pressure,regulating cell volume,and maintaining excitable membrane resting potential. The maintenance of the Na+/K+ -ATPase activity plays the important roles in neurotransmitter uptake in neurons and Ca2+ effiux. The decreased Na+/K+ -ATPase activity and dysfunction participate in the process of ischemic brain injury after cerebral ischemia. Ischemic precondi-tioning induces ischemic tolerance by maintaining the Na+/K+ -ATPase activity after ischemia.Cardiotonic steroids and citicoline may play a neuroprotective effect on cerebral ischemia by improving the Na +/K+ -ATPase activity. |
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| Keywords: | Sodium-potassium-exchanging ATPaseBrain ischemiaIschemic preconditioningCardiac glycosidesCytidine diphosphate choline |
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