| 轮状病毒感染发病机制的研究进展 |
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| 引用本文： | 周玲.轮状病毒感染发病机制的研究进展[J].国际儿科学杂志,2009,37(5):232-234. |
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| 作者姓名： | 周玲 |
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| 作者单位： | 安徽医科大学附属省立医院儿科,合肥,230001; |
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| 摘 要： | 轮状病毒(RV)是小儿腹泻病最常见病原体,RV感染不仅可导致胃肠道症状,亦可引起各种肠道外表现.RV腹泻特别是RV血症发病机制和多个因素有关,至今尚未完全明确.RV感染性腹泻可能和细胞胞间连接损害、非结构蛋白NSP4、热休克蛋白hsc70等因素有关.RV病毒血症发病机制可能和RV感染引起体内炎性介质分泌、细胞因子表达水平改变等免疫因素有关.
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| 关 键 词： | 轮状病毒 婴幼儿腹泻 病毒血症 |
Progress in the pathogenesis of rotavirus-associated disease |
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| ZHOU Ling.Progress in the pathogenesis of rotavirus-associated disease[J].International Journal of Pediatrics,2009,37(5):232-234. |
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| Authors: | ZHOU Ling |
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| Abstract: | Rotavirus is the most common pathogens of diarrheal diseases in children. Rotavirus infection lead to not only gastrointestinal symptoms but also a variety of extraintesu'nal manifestations. The pathogenesis of RV diarrhea and especially RV viremia is related to multiple factors. Rotavirus infectious diarrhea is related to the damaged cell intercellular connections,the non-structural protein 4, heat shock protein hsc70 and other factors. Pathogenesis of RV viremia may be related to the secretion of inflammatory mediators in vivo and expression of cytokines after RV infection. |
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| Keywords: | RotavirusInfantile diarrheaViremia |
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