Brain dopamine transporter: gender differences and effect of chronic haloperidol |
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Authors: | Robert Rivest Pierre Falardeau Thrse Di Paolo |
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Institution: | Robert Rivest, Pierre Falardeau,Thérèse Di Paolo, |
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Abstract: | Gender differences and the effect of chronic haloperidol on the rat brain dopamine transporter is reported. The density of striatal dopamine transporter sites labelled with 3H]GBR 12935, and of substantia nigra dopamine transporter mRNA measured by in situ hybridization were higher in female compared to male rats whereas striatal D2 specific binding labelled with 3H]spiperone was not significantly higher. Daily haloperidol treatment (1 mg/kg, i.p.) for 21 days increased striatal 3H]spiperone specific binding but left unchanged striatal 3H]GBR 12935 binding density and affinity as well as substantia nigra dopamine transporter mRNA levels. A reduce clearance rate of dopamine in the striatum after acute and chronic haloperidol was previously reported; the present results indicate that this may occur without changes in the sites of dopamine transport or in gene expression of this transporter. |
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Keywords: | Haloperidol Dopamine receptor Dopamine transporter In situ hybridization Gender effect |
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