垂体腺瘤激素分泌功能检测及临床研究

目的探讨垂体腺瘤激素分泌功能及其临床病理特点。方法采用免疫组化方法（S-P法）检测116例垂体腺瘤组织激素分泌功能并回顾性分析垂体腺瘤的临床病理特点。结果116例垂体腺瘤免疫组化检测有分泌功能腺瘤92例,其中单激素腺瘤57例,多激素腺瘤35例,无功能腺瘤23例。单激素腺瘤主要为PRL腺瘤,多激素腺瘤以PRL＋ACTH混合型腺瘤及PRL＋GH混合型腺瘤多见。垂体腺瘤的主要临床表现为头痛、性欲减退、乏力、泌乳、视力下降、毛发脱落、肢端肥大、鼻出血等。结论检测垂体腺瘤激素分泌功能有助于垂体腺瘤患者术后进行个体化综合治疗及术后随访。

The functional classification and clinicopathologic analysis of pituitary adenomas by Immunohistochemistry

Objective To study the clinical significance of the functional classification of pituitary adenomas.Methods The functional classification of 116 pituitary adenomas was measured by Immunohistochemistry method(s-p method) and clinicopathologic analysis.Results All patients,who were admitted in the Peking Union Medical College(PUMC)hospital from Jan.2005 to Oct.2006.Results Based on the functional classification of 116 pituitary adenomas,92 functioning pituitary adenomas were composed of 57 cases with simple hormone secreting adenomas,35 cases with complex functional hormone secreting adenomas,32 cases with non-functioning pituitary adenomas.The main simple hormone secreting adenomas was PRL adenomas,the main complex hormone secreting adenomas were PRL+ ACTH and PRL+GH adenomas.Conclusion This method for immunohistochemistry could be useful to apply the functional classification of pituitary adenomas,and may have clinical prospect in prevention and treatment of pituitary adenomas.