缬沙坦联合胺碘酮对阵发性心房颤动维持窦性心律的影响

目的 了解缬沙坦联合胺碘酮对阵发性：心房颤动维持窦性心律的效应。方法选择2004年1月至2007年10月笔者诊治的86例非瓣膜性阵发性心房颤动患者分为胺碘酮治疗组和缬沙坦＋胺碘酮治疗组。疗程观察1年，评价两组窦性心律的维持效果。结果治疗组左房内径明显小于对照组，窦性心律维持率明显高于对照组，结果差异有统计学：菅义。结论缬沙坦联合胺碘酮对阵发性心房颤动维持窦性心律优于单用胺碘酮治疗。可能与缬沙坦抑制肾素-血管紧张素系统，降低心脏负荷，抑制心房电及结构重构有关。

The effieaey of valsartan combined with amiodarone in maintenance of sinus rhythm in patients with paroxysmal atrial fibrillation

Objective To investigate the efficacy of valsaxtan combined with amiodarone in maintaince of sinus rhythm in patients with paroxysmal artrial fibrillation (AF). Methods From January 2004 to October 2007 ,a total of 86 consecative patients with proxysmal AF in our hospital were randomly divided into two groups: control group( amiodaxone, n = 44 ) and treating group( amiodarone plus valsartan n = 42 ). The left atrial diameter was measured with transchoracic echocarcliogram at initial therapy and after 6,12 months of treatment. Resi;ts The left atrial dimension of treating group were smaller than that of the control group. The rate of main-taining sinus rhythm in treating group was higher than that of the control group. Conclusion The results of this study suggest that the combination of amiodarone with valsartan is more effective than amiodarone alone in main-tenance of sinus rhythm.