格列吡嗪在健康志愿者体内的药物动力学及相对生物利用度

 １０名健康中国男性志愿者革剂量随机交叉ｐｏ５ｍｇ国产格列吡嗪片剂及胶囊后，采用ＨＰＬＣ法测定血浆药物浓度。结果表明ｐｏ片剂及胶囊后血药浓度达峰时间分别为２，３４±０．４０和１．８６±０．４２ｈ，峰浓度分别为２４１±６２ｆｏ２５３±５４ｎｇ／ｍｌ，药时曲线下面积分别为２０４１±６６３和２０８１±６６１ｎｇ·ｈ／ｍｌ，药时曲线符合一级吸收的单室开放模型。统计分析表明胶囊达峰时间较短，但生物利用度与片剂无显著性差异（Ｐ＞０．０５）。

Pharmacokinetics and relative bioavailability of glipizide tablets andcapsules in healthy volunteers

The pharamcokinetics and relative bioavailability of glipizide tablet and capsulewere determined after administration of a single oral dose of 5 mg to each of 10 Chinese healthymale volunteers in an open,randomized crossover study. The drug concentration in plasma was as-sayed by HPLC method.The peak levels in plasma averaged 241±62 and 253±54 ng/ml at 2.34±0.40 and 1.86±0.42 h,and the araas under the drug concentration curves were 2041±663 and2081±661 ng·h/ml for glipizide tablet and capsule,respectively. The concentration-time coursesconformed to a one compartment open model with a first order absorption. Although the capsulescould reach peak level faster,the bioavailability was not significantly different from that of thetablets.