异基因造血干细胞移植在急变期慢性粒细胞白血病治疗中的应用

 目前，急变期慢性粒细胞白血病的治疗仍然是一个较大的挑战，酪氨酸激酶抑制剂虽有一定的疗效，却并不持久，异基因造血干细胞移植是唯一可以根治该病并使患者长期生存的治疗方式。文章将对急变期慢性粒细胞白血病异基因造血干细胞移植前的治疗、预处理方案、供者、造血干细胞来源的选择、移植后微小残留病的监测、移植后复发的预防进行介绍。

Allogeneic hematopoietic stem cell transplantation for the treatment of chronic myeloid leukemia in blast crisis

The treatment for chronic myeloid leukemia is still a challenge, at present. Tyrosine kinase inhibitors can partially control chronic myeloid leukemia in blast crisis (CML-BC), but the effect is not durable. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only way that can cure CML-BC. This paper presents a review of the treatment before allo-HSCT for CML-BC, the selection of condition regimen, donor and hematopoietic stem cell, the monitoring of MRD post-transplant, the prophylaxis and intervention of relapse.