Dose-dependent proconvulsant and anticonvulsant actions of the alpha 2 adrenergic agonist, xylazine, on kindled seizures in the rat |
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| Authors: | R M Joy L G Stark T E Albertson |
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| Institution: | 1. Health Sciences Neurotoxicology Unit, School of Medicine, University of California, Davis, CA 95616, USA;2. Department of Veterinary Pharmacology and Toxicology, School of Medicine, University of California, Davis, CA 95616, USA;3. School of Veterinary Medicine, Department of Pharmacology School of Medicine, University of California, Davis, CA 95616, USA;4. School of Veterinary Medicine, Department of Pharmacology and Internal Medicines School of Medicine, University of California, Davis, CA 95616, USA |
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| Abstract: | The effects of the alpha 2 adrenergic agonist, xylazine, was evaluated on kindling acquisition and on kindled seizure expression in rats. Dose-dependent proconvulsant and anticonvulsant properties were found. The proconvulsant effects were observed at low (0.3 mg/kg) doses. In previously kindled rats these consisted of a decrease in afterdischarge threshold and an increase in the length and severity of the accompanying seizure. This dose also facilitated the rate of kindling in naive subjects. The anticonvulsant effects were observed at higher dose levels (3-20 mg/kg) which also produced sedation and ataxia. If these effects upon kindling are related to the adrenergic actions of xylazine, then it is proposed that the proconvulsant effects are associated with alpha 2 receptor activation and the anticonvulsant effects with alpha 1 receptor activation. |
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| Keywords: | Adrenergic drugs Adrenergic agonist Amygdala Seizures Nervous system Kindling Experimental epilepsy |
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