Tissue plasminogen activator inhibitor in the epidermis |
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Authors: | K. HASHIMOTO I. KATAYAMA K. NISHIOKA |
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Affiliation: | Department of Dermatology, Osaka University School of Medicine, Osaka, Japan |
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Abstract: | The presence of a tissue plasminogen activator inhibitor in the epidermis was investigated. A partially purified tissue plasminogen activator from a Bowes melanoma cell line medium was used as a tissue plasminogen activator. Extracts of epidermis dissolved in a 10 mM phosphate buffer, pH 7.0, were found to contain a tissue plasminogen activator inhibitor. The same extracts also contained a urokinase inhibitor. It is not clear whether these inhibitors are the same. This study is the first to show the existence of a tissue plasminogen activator inhibitor in the epidermis. |
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