山茱萸多糖的抗肿瘤作用及其免疫机制

目的:研究山茱萸多糖的抗肿瘤作用及其免疫机制。方法:采用S180肉瘤小鼠模型作为研究对象,观察山茱萸多糖的体内外抗肿瘤作用及其对荷瘤小鼠外周血中CD4+T细胞、CD8+T细胞、白细胞介素IL-2和白细胞介素IL-4的调节作用,并与阴性对照组进行比较。结果:山茱萸多糖对S180有明显的瘤抑制作用(P<0.01),可以使外周血CD4+T细胞表达增加,CD8+T细胞表达降低,提高白细胞介素IL-2水平、降低白细胞介素IL-4水平,且与剂量和浓度呈正相关。结论:山茱萸多糖通过调节荷瘤小鼠异常的免疫状态而发挥抗肿瘤作用。

Study on the anti-tumor effect of polysaccharides from Cornus officinalis and its immunologic mechanism

OBJECTIVE To study the anti-tumor effect of polysaccharides from Cornus officinalis and its immunologic mechanism. METHODS S180 mice were adopted to observe the anti-tumor effect of polysaccharides from Cornus officinalis and to study in vivo and in vitro immunologic mechanism of action on peripheral blood CD4+T cells,CD8+T cells,interleukin IL-2 and interleukin IL-4 in tumor-bearing mice,compared with negative control. RESULTS Polysaccharides from Cornus officinalis could apparently restrain S180 noticeably(P<0.01),increased the expression of CD4+T cells and decreased the expression of CD8+T cells in peripheral blood,and increased the level of interleukin IL-2,decreased interleukin IL-4.It had a positive correlation with dosage and concentration. CONCLUSION Polysaccharides from Cornus officinalis exerted its anti-tumor effect via the mechanism of regulative action on abnormal immunological condition in tumor-bearing mice.