化疗栓塞联合氩气刀及冷冻治疗中晚期中央型肺鳞癌近期疗效的研究

目的:探讨供血动脉化疗栓塞联合氩气刀及冷冻治疗中晚期中央型肺鳞癌的疗效、安全性和对肺功能改善影响.方法:161例中晚期中央型肺鳞癌随机分为供血动脉化疗栓塞联合氩气刀及冷冻治疗组(干预组)和单纯全身静脉化疗组(对照组),两组化疗方案均为GP方案(吉西他滨+顺铂).比较两组患者治疗6月后的临床疗效、不良反应发生及肺功能改善...

Short-term effects of Bronchial arterial chemoembolization combined with argon-heliumcryosurgical ablation for treatment of advanced central lung squamous cell carcinoma

Objective:To investigate the curative effect,safety and lung function improvement of bronchial arterial chemoembolization combined with bronchoscopy including argon-helium cryosurgical ablation for central and advanced central lung squamous cell carcinoma.Methods:161 cases of advanced central lung squamous cell carcinoma were randomly divided into bronchial arterial chemoembolization combined with bronchoscopy group(intervention group)and systemic intravenous chemotherapy group(control group).The chemotherapy regimens of both groups were GP regimens(gemcitabine+cisplatin).The clinical efficacy,the occurrence of adverse reactions and the improvement of lung function were compared between the two groups of patients after 6 months of treatment.Results:After 6 months of follow-up,the intervention group and the control group had RR of 58.62%and 36.48%,and survival rates were 93.1%(81/87)and 79.7%(59/74),respectively.The difference between the two groups was statistically significant(P<0.05).After treatment,the FEV1 and FVC indicators of the two groups were improved,and the improvement in the intervention group was also statistically significant(P<0.05).The incidence of adverse reactions was different between the two groups.The incidence of common side effects of chemotherapy in the intervention group was lower than that in the systemic intravenous chemotherapy group alone.Conclusion:Bronchial arterial chemoembolization combined with argon-helium cryosurgical ablation for advanced central lung squamous cell carcinoma is superior to traditional chemotherapy in terms of short-term efficacy,lung function improvement and safety.It has great clinical application value and is worthy of popularization and application.