外周血源性间充质干细胞修复骨关节炎软骨损伤的应用前景与问题

背景:随着近年组织工程技术应用到软骨修复研究领域,间充质干细胞作为一种具有自我更新、增殖能力强、产生克隆细胞群、多向分化等特点的成体干细胞,是软骨修复理想的种子细胞,而外周血源性间充质干细胞具有取材方便、创伤小等优点,已成为目前该领域的研究热点.目的:综述外周血源性间充质干细胞的研究现状及其在骨关节炎软骨修复中的应用,...

Application prospects and problems of peripheral blood derived mesenchymal stem cells in cartilage repair of osteoarthritis

BACKGROUND:With the application of tissue engineering technology to the cartilage repair research field in recent years,mesenchymal stem cells as a kind of adult stem cells with the characteristics of self-renewal, strong proliferation ability, clonal cell population and multidirectional differentiation, are ideal seedcells for cartilage repair. Moreover, peripheral blood derived mesenchymal stem cells, due to its conveniently, minimally invasive to the patient, have becomethe research focus in the field.OBJECTIVE: To review research status of peripheral blood derived mesenchymal stem cells and their applications in cartilage repair of osteoarthritis, to analyzethe main problems of limited clinical application and possible solutions, so as to rationally utilize peripheral blood derived mesenchymal stem cells and findsuitable seed cells for the treatment of cartilage injury.METHODS: Relevant articles collected from PubMed database, Wanfang database and CNKI Chinese journal full-text database were searched. The key wordswere “peripheral blood derived mesenchymal stem cells, circulating mesenchymal stem cells, cartilage repair, osteoarthritis treatment” in English, and“peripheral blood derived mesenchymal stem cells, circulating mesenchymal stem cells, cartilage repair, osteoarthritis” in Chinese. Finally, 57 articles wereincluded for summary.RESULTS AND CONCLUSION: The recent research on cartilage tissue engineering has increased significantly and continuously in recent years. Peripheral bloodderived mesenchymal stem cells have the advantage of chondrogenesis, can be used as more ideal seed cells in cartilage tissue engineering and have a goodclinical application prospect.