| 血小板激活因子在内毒素致狗急性肺损伤中的作用及其机理 |
| |
| 引用本文： | 李少华 陈思锋. 血小板激活因子在内毒素致狗急性肺损伤中的作用及其机理[J]. 第二军医大学学报, 1992, 13(2): 111-115 |
| |
| 作者姓名： | 李少华 陈思锋 |
| |
| 作者单位： | 第二军医大学训练部病理生理学教研室 200433(李少华，陈思锋，费侠，丁自强)，第二军医大学训练部病理生理学教研室 200433(吴中立) |
| |
| 摘 要： |
|
| 关 键 词： | 内毒素 肺水肿 磷脂酶A 狗 PAF |
Platelet-activating Factor Mediates Endotoxin-induced Lung Injury in Dogs and Its Mechanism |
| |
| Li Shaohua,Chen Sifeng,Fei Xia,Ding Ziqiang,Wu Zhongli. Platelet-activating Factor Mediates Endotoxin-induced Lung Injury in Dogs and Its Mechanism[J]. Former Academic Journal of Second Military Medical University, 1992, 13(2): 111-115 |
| |
| Authors: | Li Shaohua Chen Sifeng Fei Xia Ding Ziqiang Wu Zhongli |
| |
| Abstract: | Intravenous administration of E. coli endotoxin (2mg/kg) caused a persistent increase in platelet activating factor (PAF) contents in arterial blood and bronchoalveolar fluid (BALF). Meanwhile phospholipase A2(PLA2) activity in serum and BALF was elevated and mean arterial blood pressure declined. The total cell number, expecially polymorphonuclear leukocytes and lymphocytes, and protein concentration in BALF were markedly increased 6 h after endotoxin injection. Lung index and extravascular lung water content of endotoxin-treated animals were significantly highter than those of controls. Pretreatment with PAF receptor antagonist SRI 63-441 blocked the increase in PLA, activity and attenuated endotoxin-induced hypotension and acute lung injury. The results suggest that PAF mediates endotoxin-induced lung injury, and leukocyte activation by PAF and the subsequent release of oxygen metabolites and lysoenzymes are important intermediate mechanisms leading to high permeability pulmonary edema. |
| |
| Keywords: | platelet activating factor endotoxins pulmonary edema phospholipase A dogs |
| 本文献已被 CNKI 维普 等数据库收录！ |
