| 肾衰康延缓慢性肾衰竭进展的实验研究 |
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| 引用本文： | 朱辟疆,江丽萍,迟雨栩,韦先进,王健.肾衰康延缓慢性肾衰竭进展的实验研究[J].中国中西医结合肾病杂志,2001,2(9):508-510. |
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| 作者姓名： | 朱辟疆 江丽萍 迟雨栩 韦先进 王健 |
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| 作者单位： | 江苏省中西医结合肾脏病研究中心,镇江,212002 |
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| 基金项目： | 镇江市社会发展科技资助项目 (No .9932 0 30 ) |
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| 摘 要： | 目的：探讨肾衰康延缓慢性肾衰竭（CRF）进展的疗效及机理。方法：采用5／6肾切除大鼠CRF模型，随机分为模型组、洛汀新组及肾衰康组治疗，观察各组Scr、BUN及尿中细胞外基质成分（ECM）排泄量。结果：洛汀新组及肾衰康组Scr及BUN均显低于模型组（P＜0．01及P＜0．05），而肾衰康组Scr又低于洛汀新组（P＜0．05），肾衰康组尿中Ⅳ型胶原（Col-Ⅳ）、纤维连接蛋白（FN）及层粘连蛋白（LN）含量均明显比模型组高（P＜0．01）。结论：肾衰康有延缓CRF进展的作用，其机理可能与促进ECM成分从尿中排泄，从而减轻肾小球内ECM的聚集有关。但肾衰康对ECM是抑制合成还是促进降解尚需进一步探讨。
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| 关 键 词： | 慢性肾衰竭 肾衰康 细胞外基质 |
| 修稿时间： | 2001年2月12日 |
Experimental study of shenshuaikang on chronic renal failure rats |
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| ZHU Pijiang,JIANG Liping,CHI Yuling,et al Nephrology Researh center of Integrated Traditional Chinese and western Medicine,Jiangsu Province,Zhenjiang.Experimental study of shenshuaikang on chronic renal failure rats[J].Chinese Journal of Integrated Traditional and Western Nephrology,2001,2(9):508-510. |
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| Authors: | ZHU Pijiang JIANG Liping CHI Yuling Nephrology Researh center of Integrated Traditional Chinese and western Medicine Jiangsu Province Zhenjiang |
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| Abstract: | Objective: To study the renoprotective effect and mechanism of Shenshuaikang in chronic renal failure. Methods: 5/6 nephretomized CRF rats were divided into 3 groups: model group, Lotensin group and shenshuaikang group. Scr, BUN and urinary secretion of ECM were measured in each group. Results: Scr was lower in Lotensin and Shenshuaikang group than that in the model group (P<0.01 and P<0.05,respectively). Scr was lower in shenshuaikang group than that in Lotensin group(P<0.05). The concentration of collagen IV, fibronectin and laminin in urine were significantly higher in Shenshuaikang group than that in model group(P<0.01). Conclusion: Shenshuaikang can protect from CRF though increasing secretion of ECM in urine and decreasing accumulation of ECM in glomeruli |
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| Keywords: | Chronic renal failure Shenshuaikang Extracellular Matrix |
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