| 厌氧棒状杆菌菌苗对S_(180)抗癌效应的研究 |
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| 引用本文： | 张元杏,何宛玲,王惠芬,丁献义,郭藏珍. 厌氧棒状杆菌菌苗对S_(180)抗癌效应的研究[J]. 河北医科大学学报, 1986, 0(1) |
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| 作者姓名： | 张元杏 何宛玲 王惠芬 丁献义 郭藏珍 |
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| 作者单位： | 河北医学院微生物学教研室，河北医学院微生物学教研室，河北医学院微生物学教研室，河北医学院放射医学教研室，河北医学院放射医学教研室 |
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| 摘 要： | 本文在CFW小鼠S-180实验研究中,证明给小鼠右腋部皮下接种S-180瘤细胞后,随着肿瘤生长,动物腹腔细胞和局部淋巴结细胞的CMC和ADCC活性都下降,厌氧棒状杆菌菌苗治疗能抑制小鼠肿瘤生长,同时增强腹腔细胞和淋巴细胞的CMC和ADCC活性。
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| 关 键 词： | 菌苗 棒状杆菌属 厌氧生活 肿瘤 实验性 小鼠 雌性 |
INHIBITORY EFFECT OF ANAEROBIC CORYNEBACTERIA PARVUM VACCINE ON SARCOMA-180 |
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| Zhang Yuanxing Wang Huifen He Wanling. INHIBITORY EFFECT OF ANAEROBIC CORYNEBACTERIA PARVUM VACCINE ON SARCOMA-180[J]. Journal of Hebei Medical University, 1986, 0(1) |
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| Authors: | Zhang Yuanxing Wang Huifen He Wanling |
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| Affiliation: | Zhang Yuanxing Wang Huifen He Wanling Department of Microorganism Ding Xianyi Guo Cangzhen Department of Radio-Medicine |
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| Abstract: | It was found that both cell-mediated cytotoxicity (CMC) and antibody-dependent celluar cytotoxity(ADCC)of macrophages and lymphocytes in peritoneal cavity and lymphonodes of tumorbearing mice against S-180 tumor cells were suppressed, but both CMC and ADCG of spleen cells were enhanced. Heat-killed preparations of Vaccine strain 82-1 can significantly inhibit the growth of tumor when it was subcutaneously injected together with S180 tumor cells into the mice. At the same time GMC and ADCC of marcrophages and lymphoeytes were increased apparently in vaccine treated mice. These results indicate that the eytotoxicity of macrophages and lymphocytes in vaccine treated mice may be responsible for the inhibition of thegrowth of tumor. |
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| Keywords: | bacterial vaccine corynebacterium anaerobiosis neoplasms experimental Mice |
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