| 干扰素在肿瘤细胞凋亡信号传导通路中的作用及影响 |
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| 引用本文： | 谢风祥,毛海婷.干扰素在肿瘤细胞凋亡信号传导通路中的作用及影响[J].国外医学(肿瘤学分册),2007(6). |
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| 作者姓名： | 谢风祥 毛海婷 |
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| 作者单位： | 山东省医学科学院基础医学研究所山东省医药卫生肿瘤免疫与中药免疫重点实验室山东省现代医用药物与技术重点实验室，山东省医学科学院基础医学研究所山东省医药卫生肿瘤免疫与中药免疫重点实验室山东省现代医用药物与技术重点实验室 |
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| 基金项目： | 山东省自然科学基金资助项目(Y2002C45) |
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| 摘 要： | 干扰素(IFN)是一类具有抗病毒、抗肿瘤和免疫调节作用的细胞因子。近年来研究发现, IFN与肿瘤细胞表面受体结合后,主要通过JAK／STAT信号途径来调节一系列IFN刺激基因的表达,影响肿瘤细胞凋亡传导通路及某些凋亡调节因子,增强肿瘤细胞对凋亡信号的敏感性,诱导肿瘤细胞凋亡,从而发挥抗肿瘤效应。
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| 关 键 词： | 干扰素类 细胞凋亡 细胞色素C类 |
Effect of interferon on apoptosis signaling pathway of tumor cells |
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| XIE Feng-xiang. Key Medical Laboratory for Tumor Immunology & Chinese Medicine Immunology of Shandong Province,Key Laboratory for Modern Medicine and Technology of Shangdong Province.Effect of interferon on apoptosis signaling pathway of tumor cells[J].Foreign Medical Sciences (Cancer Section),2007(6). |
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| Authors: | XIE Feng-xiang Key Medical Laboratory for Tumor Immunology & Chinese Medicine Immunology of Shandong Province Key Laboratory for Modern Medicine and Technology of Shangdong Province |
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| Institution: | XIE Feng-xiang. Key Medical Laboratory for Tumor Immunology & Chinese Medicine Immunology of Shandong Province,Key Laboratory for Modern Medicine and Technology of Shangdong Province,Institute of Basic Medicine,Shandong Academy of Medical Science,Jinan 250062,China |
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| Abstract: | As important cytokines,interferon(IFN) family members exert multiple biological activities including initiating anti-virus,anti-cancer response and immune regulatory function. Recently, studies indicate that IFN combines to its receptor on the tumor cells surface, then modulate a series of IFN-stimulated genes mostly through JAK/STAT signaling pathways, which is correlated with apoptosis signaling pathway and apoptosis regulatory factors. IFN anti-tumor biological activites are presented mostly through enhancing the sensitivity of tumor cells to apoptosis signaling and inducing apoptosis of tumor cells. |
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| Keywords: | Interferons Apoptosis Cytochromes C |
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