| 异位hCG与恶性肿瘤关系的研究进展 |
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| 引用本文： | 王立新,熊思东. 异位hCG与恶性肿瘤关系的研究进展[J]. 中国癌症杂志, 2001, 11(3): 270-272,275 |
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| 作者姓名： | 王立新 熊思东 |
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| 作者单位： | 海基因免疫与疫苗研究中心,复旦大学免疫学教研室, |
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| 基金项目： | 上海市百人计划资助项目(编号:98BR011). |
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| 摘 要： | 异位hCG是由恶性肿细胞的胚胎基因表达的自分泌因子，其表达形式和生物学功能与胚胎滋养层细胞分泌的正常hCG存有较大的差异。本文综述了异位hCG的分子生物学特征和生物学功能，并对异位hCG与肿瘤的自我生长特点、转移特性以及肿瘤微环境和免疫耐受的形成之的关系作一探讨。
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| 关 键 词： | 人绒毛膜促性腺激素 hCG 恶性肿瘤 生物学功能 |
| 文章编号： | 1007-3639(2001)03-0270-03 |
Advances in research of the relationship between ectopic hCG and malignant tumor |
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| WANG Li xin,XIONG Si dong. Advances in research of the relationship between ectopic hCG and malignant tumor[J]. China Oncology, 2001, 11(3): 270-272,275 |
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| Authors: | WANG Li xin XIONG Si dong |
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| Abstract: | Ectopic human chorionic gonadotrophin (hCG) is an autocrine hormone expressed by most malignant tumor cells. Increasing data recently showed that the expression pattern and biological properties of ectopic hCG was significantly different from that of the normal hCG secreted by trophoblastic cells. Evidence from different research groups strongly indicated that there was a direct relationship between the expression of ectopic hCG and the development of malignant tumor. Ectopic hCG may play a key role in regulation of tumor growth,metastasis and immune tolerance versus malignant tumor. The advances in the research of the molecular biologic characteristics and functions of ectopic hCG are reviewed and evaluated. [ |
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| Keywords: | human chorionic gonadotrophin (hCG) malignant tumor biologic function |
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