蔓性千斤拔化学成分的研究

从豆科植物蔓性千斤拔Flemingia philippinensis(Merr.et Rolfe)Li]的根中分得六个化合物和一个烷酸的混合物(Ⅰ～Ⅶ)。经理化常数测定和光谱分析证明,化合物Ⅰ和Ⅱ为新化合物,分别命名为蔓性千斤拔素C(Ⅰ)和蔓性千斤拔素D(Ⅱ),其余为已知物,分别鉴定为5,7,3′,4′-四羟基-6,8-双异戊烯基异黄酮(Ⅲ),flemichin D(Ⅳ),n C₂₂～C₃₀烷酸(Ⅴ),β-谷甾醇(Ⅵ)和羽扇豆醇(Ⅶ)。化合物Ⅲ和Ⅳ对P₃₈₈白血病细胞具有显著的抑制作用。

STUDIES ON THE CHEMICAL CONSTITUENTS OF FLEMINGIA PHILIPPINENSIS

Two new prenylated flavonoids, flemiphilippinin C (I) and flemiphilippinin D (II) have been isolated from the root of Flemingia philippinensis (Merr. et Rolfe) Li along with four known compounds. The structure of I and II were elucidated as 7-(.4'-hydroxy-3'-methoxyphenyl)-5-hydroxy-2, 2-dimethyl-10-prenyl-2H,6H-benzo-1,2-b:5,4-b']dipyran-6-one and 5,7,2',4'-tetrahydroxy-6,8-diprenylisoflavanone, respectively, on the basis of chemical and spectroscopic data. The four known compounds were identified as 5,7,3',4'-tetrahydroxy-6,8-diprenylsilflavone (III), flemichin D (IV), beta-sitosterol (VI) and lupeol (VII), and a mixture of n C22-C30 aliphatic acid (V). Compounds III and IV showed significant cytotoxic activities against P388 cell cultures.