| 基因工程IFNα_(2a)对肿瘤细胞生长的抑制作用 |
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| 引用本文： | 缪竞诚,杨吉成,李丽娥,盛伟华,董宁征,徐伦. 基因工程IFNα_(2a)对肿瘤细胞生长的抑制作用[J]. 苏州大学学报(自然科学版), 1999, 0(6) |
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| 作者姓名： | 缪竞诚 杨吉成 李丽娥 盛伟华 董宁征 徐伦 |
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| 作者单位： | 苏州医学院生物技术研究所!215007 |
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| 摘 要： | 采用α－干扰素抑制各种肺癌细胞生长的MTT法。结果：不同品牌的10000，1000，100IU／ml的IFNα2a对人脑胶质瘤细胞（SHG—44）、人骨肉瘤细胞（HOS－8603）、人白血病细胞（HL－60）、红白血病细胞（K562）和淋巴瘤细胞（Raji）的生长抑制率分别为20％，10％，5％左右。结论：进口和国产的不同品牌IFNα2a。对上述5种肿瘤细胞株均有较明显的生长抑制效应，且抑制率相近。
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| 关 键 词： | 不同类型干扰素 肿瘤细胞 生长抑制率 |
The Study on the Anti-Cox B_3 Virus Effect of Recombinant Interferon-a_(2a) in Wish Cell lines |
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| Liao Jingcheng,et al. The Study on the Anti-Cox B_3 Virus Effect of Recombinant Interferon-a_(2a) in Wish Cell lines[J]. Suzhou University Journal of Medical Science, 1999, 0(6) |
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| Authors: | Liao Jingcheng et al |
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| Affiliation: | Medical Biotechnological Institute of Suzhou Medical College |
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| Abstract: | In the present report we used the method of microdose cytopathogenic inhibition effect assay to study the anti-CoxB3 virus effect of recornbinant intefferon-a2a in Wish cell lines. The results indicated that both Wandferon and Roferon -A exhibited antiviral effect obviously. In our experiment 500IU/ml, 50IU/ml and 5IU/ml of IFN - a2a can preventWish cells from idecting by CoxB3 virus of 3 log4, 2 log4 and 1 log4 TCID50 respectively. The results als0 suggested thatthere were no apparent differeces between Wandferon and Rofemo-A. |
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| Keywords: | recornbinant interfelnn-a2a antiviral effect Coxsakie virtls - B3 |
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