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Growth and growth hormone in Turner syndrome: Looking back,looking ahead |
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| Authors: | Evan Los Ron G. Rosenfeld |
| Affiliation: | 1. https://orcid.org/0000-0002-7567-0178;2. Department of Pediatrics, Division of Pediatric Endocrinology, East Tennessee State University, Johnson City;3. Evan Los, Department of Pediatrics, Division of Pediatric Endocrinology, East Tennessee State University, 408 N State of Franklin Rd, Suite 31B Johnson City, TN 37604.;4. Oregon Health & Science University, Portland, Oregon |
| Abstract: | Short stature is the most ubiquitous feature of Turner syndrome (TS). Today, many girls with TS are treated with recombinant human growth hormone (GH) to accelerate growth in childhood and to improve adult height. Here, we will review the history of our understanding of growth in TS, reflect on the path of clinical trials ultimately leading to regulatory approval for clinical use of GH, discuss factors associated with growth outcomes and survey the current unanswered questions about growth and GH in TS. |
| Keywords: | growth growth hormone Turner syndrome |