A heterozygous,intragenic deletion of CNOT2 recapitulates the phenotype of 12q15 deletion syndrome |
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| Authors: | Viola Alesi Sara Loddo Federica Calì Valeria Orlando Silvia Genovese Daniele Ferretti Chiara Calacci Giusy Calvieri Roberto Falasca Lucia Ulgheri Fabrizio Drago Bruno Dallapiccola Anwar Baban Antonio Novelli |
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| Affiliation: | 1. https://orcid.org/0000-0001-7514-5683;2. Department of Medical Genetics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy;3. Viola Alesi, Department of Medical Genetics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.;4. Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy;5. Department of Biomedical Sciences, Clinical Genetics Service, Azienda Ospedaliero‐Universitaria, Sassari, Italy |
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| Abstract: | Only a few individuals with 12q15 deletion have been described, presenting with a disorder characterized by learning disability, developmental delay, nasal speech, and hypothyroidism. The smallest region of overlap for this syndrome was included in a genomic segment spanning CNOT2, KCNMB4, and PTPRB genes. We report on an additional patient harboring a 12q15 microdeletion encompassing only part of CNOT2 gene, presenting with a spectrum of clinical features overlapping the 12q15 deletion syndrome phenotype. We propose CNOT2 as the phenocritical gene for 12q15 deletion syndrome and its haploinsufficiency being associated with an autosomal dominant disorder, presenting with developmental delay, hypotonia, feeding problems, learning difficulties, nasal speech, skeletal anomalies, and facial dysmorphisms. |
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| Keywords: | 12q15 12q deletion syndrome CNOT2 |
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