| 上皮间质转化相关长链非编码RNA与胃癌的关系 |
| |
| 引用本文： | 李江,袁士杰,聂明明. 上皮间质转化相关长链非编码RNA与胃癌的关系[J]. 第二军医大学学报, 2019, 40(2): 209-212 |
| |
| 作者姓名： | 李江 袁士杰 聂明明 |
| |
| 作者单位： | 海军军医大学(第二军医大学)长海医院普通外科, 上海 200433*通信作者 |
| |
| 基金项目： | 国家自然科学基金（81472277）. |
| |
| 摘 要： | 胃癌是威胁人类健康的主要恶性肿瘤之一，其发生涉及多步骤、多基因的相互作用过程。上皮间质转化（EMT）是上皮细胞通过特定程序转化为有间质表型细胞的过程。研究表明长链非编码RNA（lncRNA）可以通过与靶蛋白结合、作为竞争性内源RNA竞争微RNA等方式促进或抑制EMT过程，且许多特异表达的EMT相关lncRNA与胃癌的侵袭、转移密切相关。本文主要就EMT相关lncRNA在胃癌侵袭和转移中的调控机制作一综述。
|
| 关 键 词： | 上皮间质转化 长链非编码RNA 胃肿瘤 肿瘤侵袭 肿瘤转移 |
| 收稿时间： | 2018-07-15 |
| 修稿时间： | 2018-09-18 |
Epithelial-mesenchymal transition-related long non-coding RNA and gastric cancer |
| |
| LI Jiang,YUAN Shi-jie and NIE Ming-ming. Epithelial-mesenchymal transition-related long non-coding RNA and gastric cancer[J]. Former Academic Journal of Second Military Medical University, 2019, 40(2): 209-212 |
| |
| Authors: | LI Jiang YUAN Shi-jie NIE Ming-ming |
| |
| Affiliation: | Department of General Surgery, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China*Corresponding author |
| |
| Abstract: | Gastric cancer is one of the main malignancies threatening human health, and its occurrence involves multistep and multigene interactions. Epithelial-mesenchymal transition (EMT) is a biological process in which epithelial cells transform to mesenchymal phenotypic cells through specific procedures. Studies have shown that long non-coding RNAs (lncRNAs) can promote or inhibit EMT by binding to target proteins and competing microRNAs as competitive endogenous RNAs, and some specific EMT-related lncRNAs are deeply involved in the invasion and metastasis of gastric cancer. In this review, we summarized the recent mechanisms of EMT-related lncRNAs in the regulating the invasion and metastasis of gastric cancer. |
| |
| Keywords: | epithelial-mesenchymal transition long non-coding RNA stomach neoplasms neoplasm invasiveness neoplasm metastasis |
|
| 点击此处可从《第二军医大学学报》浏览原始摘要信息 |
|
点击此处可从《第二军医大学学报》下载全文 |
