| 辛伐他汀缓释片制备及体外释放研究 |
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| 引用本文： | 石雷, 钱俊青. 辛伐他汀缓释片制备及体外释放研究[J]. 中国现代应用药学, 2011, 28(11): 1013-1017. |
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| 作者姓名： | 石雷 钱俊青 |
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| 作者单位： | 1.浙江工业大学药学院，杭州 310014;2.台州职业技术学院，浙江 台州 318000 |
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| 摘 要： | 目的 制备辛伐他汀凝胶骨架缓释片，对影响药物释放的因素进行考查。方法 采用紫外分光光度法测定其体外释放度，应用湿法制粒压片法制备缓释片，以羟丙基甲基纤维素(HPMC)为骨架材料，考察了HPMC规格、用量及其它辅料对药物释放的影响，并进行了正交实验优化及处方和制备方法的验证。结果 辛伐他汀缓释片的体外释放受HPMC规格、HPMC用量、粘合剂种类的影响，选择HPMC(K15M)为骨架材料，其与主药质量比为1.5∶1，所制缓释片能持续释药12 h，批间重现性良好。结论 该制剂处方合理，制备方法可行，具有良好的缓释效果。
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| 关 键 词： | 辛伐他汀 凝胶骨架缓释片 羟丙基甲基纤维素 释放度 |
| 收稿时间： | 2011-04-01 |
| 修稿时间： | 2011-06-23 |
Preparation and Study on Release Rate in Vitro for Sustained-release Tablets of Simvastatin |
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| SHI Lei, QIAN Junqing. Preparation and Study on Release Rate in Vitro for Sustained-release Tablets of Simvastatin[J]. Chinese Journal of Modern Applied Pharmacy, 2011, 28(11): 1013-1017. |
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| Authors: | SHI Lei QIAN Junqing |
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| Affiliation: | 1.College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China; 2.Taizhou Vocational ＆ Technical College, Taizhou 318000, China |
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| Abstract: | OBJECTIVE To prepare gel matrix sustained-release tablets of simvastatin and examine the factors affecting drug release rates.METHODS Assay the release rates in vitro by UV spectrophotometry,prepare the sustained-release tablets by wet granulation squash method with hydroxypropyl methyl cellulose(HPMC) as matrix material,examine the impact on the release rates with the specification and quantity of HPMC and other excipients,optimize the formulation with orthogonal test method and validate the preparation me... |
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| Keywords: | simvastatin gel matrix sustained-release tablets hydroxypropyl methyl cellulose release rate |
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