| “张氏三伏贴”抗哮喘组方优化研究 |
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| 引用本文： | 上官盈盈,王玮. “张氏三伏贴”抗哮喘组方优化研究[J]. 中国现代应用药学, 2011, 28(11): 1003-1006 |
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| 作者姓名： | 上官盈盈 王玮 |
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| 作者单位： | 浙江医学高等专科学校，杭州 310053 |
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| 基金项目： | 浙江省中医药管理局资助项目(2007CA093) |
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| 摘 要： | 目的以均匀试验法筛选优化中药＂张氏三伏贴＂的处方组成。方法使豚鼠吸入雾化2%氯化乙酰胆碱和0.1%磷酸组胺生理盐水溶液诱发哮喘。以均匀试验设计对＂张氏三伏贴＂处方进行拆方,分析其抗哮喘的组方。结果本试验最终确定了＂张氏三伏贴＂对抗豚鼠急性诱发型哮喘的最佳处方组成为：麻黄、甘遂（生）、白芥子（炒）、细辛,其最佳剂量比为：200 mg.kg-1：75 mg.kg-1：100 mg.kg-1：150μL.kg-1。结论以此配伍组成的＂张氏三伏贴＂组方和阴性对照组相比较抗喘效果良好,安全性高。此组方的优化研究将为张氏三伏贴复方制剂开发提供依据。
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| 关 键 词： | 三伏贴 哮喘 组方优化 均匀试验 |
| 收稿时间： | 2011-04-01 |
| 修稿时间： | 2011-07-15 |
Study on Optimized Formula of Zhang's Dog-days Paste for Treating Asthma |
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| SHANGGUAN Yingying,WANG Wei. Study on Optimized Formula of Zhang's Dog-days Paste for Treating Asthma[J]. The Chinese Journal of Modern Applied Pharmacy, 2011, 28(11): 1003-1006 |
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| Authors: | SHANGGUAN Yingying WANG Wei |
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| Affiliation: | Zhejiang Medical College, Hangzhou 310053, China |
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| Abstract: | OBJECTIVE To optimize the formula of Zhang's dog-days paste by uniform design.METHODS 2% acetylcholine chloride and 0.1% histamine phosphate in physiological saline solution were used to induce asthma in guinea pig.The uniform design was applied to decompose the Zhang's dog-days paste and evaluate its effect in treating asthma.RESULTS It was concluded that Ephedra,raw Kansui Root,fried Semen sinapis and Asarum oil were the effect components of Zhang's dog-days paste in treating asthma.The optimal dose ratio... |
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| Keywords: | dog-days paste asthma optimization of formula uniform test |
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